From Ellsworth, take Route 3 South, following the signs to Mount Desert Island. Just after you come onto the Island, the road forks at a stop light. Bear RIGHT onto Route 102. Proceed on Rte. 102 until you come to a second traffic light. Turn LEFT at the light, onto Route 3/198. Continue STRAIGHT on Rte. 3/198 toward Northeast Harbor. Just before you reach the town, you pass a large stone-walled gate house on your left. At the bottom of that hill, turn left into the parking lot for the Garden.

The Azalea Garden is also accessible via the Island Explorer bus.